← Frozen shoulder (adhesieve capsulitis)-overzicht

Referenties frozen-shoulder-dossier

Dit dossier is gebaseerd op een lokale literatuursynthese (PubMed, OpenAlex en full-text) van meta-analyses, systematische reviews, case-control studies, een cohortstudie en mechanistisch dier- en celonderzoek. Per claim is in de hoofdstukken de PMID vermeld. Hieronder de volledige lijst.

Oorzaken, epidemiologie en risicofactoren

• PMID 41896299 - The diabetic shoulder: association between diabetes mellitus and adhesive capsulitis - a systematic review and meta-analysis. International Orthopaedics, 2026. (Diabetes OR 3,69.)
• PMID 39344847 - Are patients with newly diagnosed frozen shoulder more likely to be diagnosed with type 2 diabetes? A cohort study in UK electronic health records. Diabetes, Obesity & Metabolism, 2024. (HR ~19-20 voor latere type-2-diabetes.)
• PMID 24438046 - Case control study of risk factors for frozen shoulder in China. International Journal of Rheumatic Diseases, 2015. (Diabetes, trauma, schildklier, BMI, cervicale spondylose.)
• PMID 35447316 - Involvement of inflammatory lipoproteinemia with idiopathic adhesive capsulitis accompanying subclinical hypothyroidism. Journal of Shoulder and Elbow Surgery, 2022. (Subklinische hypothyreoïdie OR 2,10.)
• PMID 39882261 - The association between primary frozen shoulder and serum lipids may be overestimated: evidence based on retrospective observational studies and Mendelian randomization. Frontiers in Endocrinology, 2024. (Lipiden-verband causaal niet bevestigd.)

Pathofysiologie en pathways

• PMID 31340682 - Biomarkers associated with idiopathic frozen shoulder: a systematic review. Connective Tissue Research, 2020. (Cytokines, MMP/TIMP-ratio, ASIC, melatonine, globale fibroplasie.)
• PMID 10963182 - Expression of growth factors, cytokines and matrix metalloproteinases in frozen shoulder. The Journal of Bone and Joint Surgery (British), 2000. (Collageen type I/III, myofibroblasten, ontbreken MMP-14, Dupuytren-vergelijking.)
• PMID 27039673 - The effect of myofibroblasts and corticosteroid injections in adhesive capsulitis. Journal of Shoulder and Elbow Surgery, 2016. (Alfa-SMA-myofibroblasten, effect corticosteroïd.)
• PMID 27351864 - The Treatment of Fibrosis of Joint Synovium and Frozen Shoulder by Smad4 Gene Silencing in Rats. PLoS One, 2016. (TGF-beta/Smad-route, immobilisatiemodel.)
• PMID 34526039 - Recombinant TSG-6 protein inhibits the growth of capsule fibroblasts in frozen shoulder via suppressing the TGF-beta/Smad2 signal pathway. Journal of Orthopaedic Surgery and Research, 2021.

Natuurlijke stoffen en interventies

• PMID 34044279 - Tetrandrine inhibits the occurrence and development of frozen shoulder by inhibiting inflammation, angiogenesis, and fibrosis. Biomedicine & Pharmacotherapy, 2021. (Ratmodel.)

Psyche en centrale sensitisatie

• PMID 35270316 - A Central Nervous System Focused Treatment Program for People with Frozen Shoulder: A Feasibility Study. International Journal of Environmental Research and Public Health, 2022.

Cortisol, glycatie en de AGE-RAGE-route

• PMID 32279986 - RAGE-dependent NF-kB inflammation processes in the capsule of frozen shoulders. Journal of Shoulder and Elbow Surgery, 2020.
• PMID 33205235 - The puzzling pathophysiology of frozen shoulders - a scoping review. Journal of Experimental Orthopaedics, 2020.
• PMID 23690694 - Management of limited joint mobility in diabetic patients. Diabetes, Metabolic Syndrome and Obesity, 2013.
• PMID 12958202 - The breakdown of preexisting advanced glycation end products is associated with reduced renal fibrosis in experimental diabetes. FASEB Journal, 2003.
• PMID 7557125 - Corticosteroids increase procollagen gene expression, synthesis, and secretion by human intestinal smooth muscle cells. Gastroenterology, 1995.

Mitochondriën en metabolisme

• PMID 40845125 - Involvement of Oxidative Stress and Glycation Stress in Frozen Shoulder. The Journal of Bone and Joint Surgery (American), 2025.
• PMID 23204521 - Mitochondrial reactive oxygen species regulate transforming growth factor-β signaling. Journal of Biological Chemistry, 2013.
• PMID 32673537 - Myofibroblasts and Fibrosis: Mitochondrial and Metabolic Control of Cellular Differentiation. Circulation Research, 2020.
• PMID 23769708 - Thyroid hormones and mitochondria: with a brief look at derivatives and analogues. Molecular and Cellular Endocrinology, 2013.
• PMID 32941310 - Assessment of Mitochondrial Dysfunction in a Murine Model of Supraspinatus Tendinopathy. The Journal of Bone and Joint Surgery (American), 2021.
• PMID 29857907 - Vitamin D deficiency may stimulate fibroblasts in Dupuytren’s disease via mitochondrial increased reactive oxygen species through upregulating transforming growth factor-β1. Medical Hypotheses, 2018.

Zuurstof en hypoxie

• PMID 16990020 - Expression of vascular endothelial growth factor and angiogenesis in the diabetic frozen shoulder. Journal of Shoulder and Elbow Surgery, 2006.
• PMID 31311941 - Hypoxia-induced epithelial-mesenchymal transition and fibrosis for the development of breast capsular contracture. Scientific Reports, 2019.
• PMID 25276370 - Adiponectin protects rat heart from left ventricular remodeling induced by chronic intermittent hypoxia via inhibition of TGF-β/smad2/3 pathway. Journal of Thoracic Disease, 2014.
• PMID 40833928 - The relationship between obstructive sleep apnea and atrial remodeling, fibrosis and inflammation. PLoS One, 2025.
• PMID 40405523 - Interruption of intermittent hypoxia attenuates the severity of pulmonary fibrosis in male mice. Physiological Reports, 2025.
• PMID 27477625 - Association of Musculoskeletal Joint Pain With Obstructive Sleep Apnea, Daytime Sleepiness, and Poor Sleep Quality in Men. Arthritis Care & Research, 2017.
• PMID 5135380 - Relationships between pleuro-pulmonary lesions and scapulo-humeral periarthritis. Minerva Ortopedica, 1971.

Disclaimer

Dit dossier is een samenvatting van wetenschappelijke literatuur ten behoeve van professionals en geïnformeerde gebruikers. Het is geen medisch advies en vervangt geen consult, diagnose of behandeling door een arts. Beslissingen over medicatie, suppletie of leefstijl horen individueel met een zorgverlener te worden afgestemd.