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Kernbronnen ziekte van Parkinson

Hoe deze lijst is opgebouwd

De bronnen komen uit een lokale PubMed-OpenAlex zoekopdracht van 20 mei 2026 over drie domeinen: risicofactoren en pathofysiologie, suppletie en nutraceutica, en lifestyle-interventies. In totaal werden 674 artikelen opgehaald; hieronder de kernbronnen waarop dit dossier is gebaseerd, gegroepeerd per hoofdstuk en met design-niveau.

Citatie-aantallen en publicatiejaren zijn momentopnamen van mei 2026.

Pathofysiologie

PMIDTitelDesignJaar
41949708Parkinson’s disease: pathogenesis and therapeutic strategiesNarrative review2026
41045318The Mitochondrial-Astrocyte-Neuron Triad Hypothesis in Parkinson’s DiseaseNarrative review2025
41258873Pathogenic mechanism underlying parkinsonism induced by neurotoxicants and α-synucleinNarrative review2026
42028943A “prion mechanism” involved in the progression of Parkinson’s diseaseNarrative review2026
38059801Multimodal assessment of mitochondrial function in Parkinson’s diseaseJournal article2024
42003321Comparative evaluation of oxidative stress biomarkers F2-isoprostanes and 8-OHdGMeta-analysis2026
41126461Iron on trial: recasting the role of iron in neurodegenerationNarrative review2025
39026990Causal associations between oxidative stress and Parkinson’s disease (Mendelian randomization)Journal article2024
42096963Targeting TLR4 in Parkinson’s disease: mechanisms and therapeutic prospectsNarrative review2026
42144052IKK-β inhibition as a precision therapeutic approach to disrupt the NF-κB neuroinflammatory cascadeNarrative review2026
42123298Systemic Endotoxemia, Inflammatory Activation, and Lipid Dysregulation in Parkinson’s DiseaseCase-control study2026
38050970Glutathione Depletion in Patients with Parkinson’s DiseaseJournal article2023
41621636α-Synuclein seed amplification assay performance: meta-analysisMeta-analysis2026
41603154Clinical Validation of α-Synuclein in Salivary Extracellular Vesicles as Biomarker for PDCohort study2026
40011434Dysregulation of mitochondrial α-ketoglutarate dehydrogenase leads to elevated lipid peroxidation in CHCHD2-linked PDJournal article2025

Risicofactoren

PMIDTitelDesignJaar
41940964Genetic and environmental risk factors of ParkinsonismNarrative review2026
42074567Genetic Associations of Parkinson’s Disease Clinical, Pathological, and Data-Driven SubtypesJournal article2026
41952858Cortical, subcortical, and cerebellar atrophy in teens and young adults exposed to PM2.5Journal article2026
39601947Ferroptosis in the Substantia Nigra Triggered by Ultrafine Diesel Exhaust ParticlesJournal article2024
41977181Copper Dyshomeostasis Affects α-Synuclein Clearance Mechanisms in PDNarrative review2026
42076898Copper Overload Affects α-Synuclein Clearance Mechanisms in a PD In Vitro ModelJournal article2026
42148602When copper turns killer: cuproptosis in neurodegenerative pathogenesisNarrative review2026
42121905GLP-1 and Parkinson’s Disease: A Comprehensive Review of Biology, Mechanisms and EfficacyNarrative review2026

Gut-brain axis

PMIDTitelDesignJaar
42074174Gut-Brain Signaling in Parkinson’s Disease: A Narrative ReviewNarrative review2026
41586427Gut-Brain Axis: Role of Gastrointestinal Issues in Parkinson’s DiseaseNarrative review2025
42115189Aggregation in gut: on the link between neurodegeneration and bacterial functional amyloidsJournal article2026
42083540The Gut-Brain Connection in Parkinson’s DiseaseJournal article2026
40614920Parkinson’s disease and the gut microbiota connectionNarrative review2025
42062487Prebiotic intervention changes host and microbe proteomes in PD plasma exosomesJournal article2026
41884318Mediterranean diet and gut microbiota: impact on memory and cognitive functionsSystematic review2026
42117754Beyond the Gut-Brain Axis Hypothesis: Critical ConsiderationsEditorial2026
41759265Intermittent fasting protects MPTP-induced PD mouse model through regulating gut microbiota dysbiosisJournal article2026

Suppletie

PMIDTitelDesignJaar
34607196Neuroaspis PLP10 omega-3/6 RCT in early Parkinson’s disease (30 months)RCT2021
38923542Omega-3 polyunsaturated fatty acids and PD: systematic review of animal studiesSystematic review2024
36555817EPA enhances neurotrophic factor expression and protects against parkinsonian cell deathJournal article2022
26343714Associations between B Vitamins and Parkinson’s Disease (meta-analysis)Meta-analysis2015
24532985Homocysteine Level and Mechanisms of Injury in PD as Related to L-Dopa TreatmentJournal article2013
36922273Levodopa, homocysteine and Parkinson’s diseaseNarrative review2023
28608472Peripheral neuropathy in 30 duodopa patients with vitamins B supplementationJournal article2017
41977262N-Acetylcysteine in Neurological Disorders: Systematic Review of Clinical EvidenceSystematic review2026
38705493Efficacy of probiotic supplements on Parkinson’s disease (meta-analysis 11 RCTs)Meta-analysis2024
38805039Co-administration of probiotics and vitamin D in PD: RCTRCT2024
37555855Does vitamin D protect or treat Parkinson’s disease? Narrative reviewNarrative review2024
37731327The neuroprotective effect of vitamin D in Parkinson’s diseaseNarrative review2024
42037680Targeting VDR-RXR heterodimerization in neurodegenerative diseasesJournal article2026
26505466Long-Term Treatment with High-Dose Thiamine in PD: Open-label PilotPilot study2015
28577542Effectiveness of creatine for Parkinson’s disease: meta-analysis (NEGATIVE)Meta-analysis2017
38262563Creatine + exercise reduces α-synuclein oligomerization in PD mouse modelJournal article2024
17312085Resistance training with creatine improves upper-body strength in PD: RCTRCT2007
38730474Serum urate levels and neurodegenerative outcomes: cohort + Mendelian randomizationCohort + MR2024
37308056Alpha lipoic acid ameliorates motor deficits by inhibiting ferroptosis in PDJournal article2023
39127301Neuroprotective effects of alpha lipoic acid in rotenone-induced PDJournal article2024
40763886Alpha lipoic acid regulates dopaminergic neuronal damage via Nrf2/HMOX1Journal article2025
42042751Alpha-Lipoic Acid and Biotin in Neurodegenerative Diseases: Convergent InsightsNarrative review2026
36034698Curcumin reprograms gut microbiota and ameliorates motor deficits in PD miceJournal article2022
39724731Curcumin prevents neurodegeneration via HDAC6-NLRP3 in PDJournal article2025
42126821Dietary supplements for Parkinson’s disease: State of the scienceNarrative review2026

Lifestyle

PMIDTitelDesignJaar
36602886Physical exercise for people with Parkinson’s disease: Cochrane network meta-analysis (156 RCT’s)Cochrane NMA2023
34997759Parkinson’s disease and intensive exercise therapy: updated meta-analysisMeta-analysis2022
39880702Optimal dose and type of exercise for motor symptoms in PD: network meta-analysisNMA2025
35754291Effects of Resistance Training on Motor and Non-Motor Symptoms in PDMeta-analysis2022
36265444Effectiveness of Progressive Resistance Training in PDMeta-analysis2023
39962570Tai Chi improves balance, mobility and gait in PD: meta-analysisMeta-analysis2025
39841325Effects of different types of Tai Chi intervention on motor function in older adultsSystematic review2025
41259881Mediterranean diet for prevention of neurological diseases: meta-analysisMeta-analysis2026
41492937Adherence to MED and MIND Diets and PD Incidence in Women (E3N prospective cohort)Cohort study2026
41521425Mediterranean-DASH (MIND) diet and brain health: systematic reviewSystematic review2026
41666212Plant-rich, time-restricted nutritional intervention for PD: RCTRCT2026
41637153Mediterranean-ketogenic interventions in PD: random-order crossover trialCrossover RCT2026
40368903Intermittent fasting reduces α-synuclein pathology in a PD mouse modelJournal article2025
41759265Intermittent fasting protects MPTP-induced PD via gut microbiotaJournal article2026
41356819Effects of intermittent fasting on brain health via the gut-brain axisNarrative review2025
40288252Effect of melatonin on sleep quality and daytime sleepiness in PD: meta-analysisMeta-analysis2025
40588412Effectiveness of Melatonin for Sleep Disturbances in Parkinson Disease: meta-analysisMeta-analysis2026
40387966Melatonin in managing sleep and motor symptoms in PD: pooled analysis of RCTsMeta-analysis2025
38043930Acupuncture on sleep quality in PD patients: meta-analysisMeta-analysis2024
41296768Exercise for enhancing sleep quality in PD: systematic review and meta-analysisMeta-analysis2025
41168406Sleep deprivation and risk for Parkinson’s disease: evidence and therapeutic implicationsNarrative review2025
40982332Obstructive sleep apnea in Parkinson’s disease and motor symptom burdenJournal article2025
41160948Effects of REM Sleep Behaviour Disorder medications on dream content: critical reviewSystematic review2025

Voeding en risico

PMIDTitelDesignJaar
41252180Foods and Dietary Intakes and the Risk of Parkinson’s Disease: dose-response meta-analysis of prospective cohortsMeta-analysis2025
39693849Association between Mediterranean diet adherence and Parkinson’s disease: systematic review and meta-analysisMeta-analysis2025
36961747Vitamin C, vitamin E, β-carotene and risk of Parkinson’s disease: dose-response meta-analysisMeta-analysis2024
41544344Association between dairy consumption and Parkinson’s disease: systematic review and meta-analysisMeta-analysis2026
38753992Ultra-processed food intake and neurodegenerative disorders: dose-response meta-analysisMeta-analysis2025
37941998Plasma homocysteine, vitamin B12 and folate levels and Parkinson’s disease: systematic review and meta-analysisSystematic review2023
42259394Natural Monomer Compounds in Neurodegenerative Diseases: Targeting Ferroptosis and NeuroinflammationNarrative review2026
42121268Neuroprotective effects of quercetin in animal models of neurodegenerative diseases: meta-analysisMeta-analysis2026
42093988Resveratrol and the neuroinflammation axis in Alzheimer’s, Parkinson’s, MS, cerebral ischemiaNarrative review2026

Medicatie en werkingsmechanismen

PMIDTitelDesignJaar
41949708Parkinson’s disease: pathogenesis and therapeutic strategiesNarrative review2026
36922273Levodopa, homocysteine and Parkinson’s diseaseNarrative review2023
24532985Homocysteine Level and Mechanisms of Injury in PD as Related to L-Dopa TreatmentJournal article2013
28608472Peripheral neuropathy in 30 duodopa patients with vitamins B supplementationJournal article2017
28523235Levodopa/carbidopa intestinal gel vs oral on B vitamin levels and neuropathyJournal article2017
42121905GLP-1 and Parkinson’s Disease: Biology, Mechanisms and EfficacyNarrative review2026
41206637M14 substitutions in exenatide modulate alpha-synuclein aggregationJournal article2026
42133141Purinergic modulation in PD: dual role of istradefyllineNarrative review2026
41702332α-synuclein monoclonal antibodies in PD: failed promise or unmet potential?Narrative review2026
42064986Levodopa-accelerated frailty: a hypothesis for cumulative iatrogenic burdenJournal article2026
37565888DBS of the subthalamic nucleus improves sleep in PD: meta-analysisMeta-analysis2023

Hoe te citeren

Wie naar dit dossier verwijst: “Health Cockpit Research — Ziekte van Parkinson dossier, geraadpleegd op [datum], beschikbaar via research.healthcockpit.be/conditions/parkinson/.”

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