Health Cockpit Research

Onderdeel van het Aambeien (hemorroïdale ziekte)-dossier van Health Cockpit, het praktijkmanagement-platform voor functioneel werkende therapeuten.

Referenties (PubMed, OpenAlex)

Alle bronnen die in dit dossier zijn gebruikt, gesorteerd per thema, met PubMed ID en directe link. Het evidence level is gebaseerd op studieopzet, niet op een inhoudelijke appraisal. Dit dossier is samengesteld met de research-local pipeline (PubMed + OpenAlex) en dubbel gereviewd op wetenschappelijke juistheid, bronnendekking en compliance.

Richtlijn en overzicht

PMID	Titel	Tijdschrift	Jaar
42067175	AGA Clinical Practice Update on Diagnosis and Treatment of Hemorrhoids	Clin Gastroenterol Hepatol	2026
40458338	Natural Products in Hemorrhoid Management: A Comprehensive Literature Review	Cureus	2025
40740911	TONEFACT: Can even advanced hemorrhoids be treated without surgery?	World J Gastrointest Surg	2025

Pathofysiologie, genetica en hypotheses

PMID	Titel	Tijdschrift	Jaar
33888516	Genome-wide analysis of 944.133 individuals provides insights into the etiology of haemorrhoidal disease	Gut	2021
41879548	Integrative genomic analysis of missense mutations and target genes in hemorrhoid pathogenesis	Folia Medica	2026
36983199	Altered Gut Microbic Flora and Haemorrhoids: Could They Have a Possible Relationship?	J Clin Med	2023
42443290	Puji Zhichuang suppositories alleviate hemorrhoid-like anorectal inflammation via PI3K-Akt	Sci Rep	2026
42257743	Early hemodynamic changes following endoscopic sclerotherapy assessed by transperineal ultrasound	Int J Colorectal Dis	2026

Epidemiologie en risicofactoren

PMID	Titel	Tijdschrift	Jaar
40115576	Prevalence and risk factors of hemorrhoids in Jazan Region, Saudi Arabia	J Family Med Prim Care	2025
42175480	Causal associations between lifestyle factors and hemorrhoidal disease: Mendelian randomization	Medicine	2026
41987108	Association between varicocele and hemorrhoidal disease in men presenting with groin pain	BMC Urology	2026
42452479	The Impact of Symptoms of Benign Anorectal Disorders on Self-Esteem and Depression in Postpartum Women	J Clin Med	2026

Behandeling: meta-analyses en RCT’s (evidence level A)

PMID	Titel	Tijdschrift	Jaar
32399811	Micronized Purified Flavonoid Fraction in Hemorrhoid Disease: Systematic Review and Meta-Analysis	Adv Ther	2020
30012392	Efficacy and tolerability of MPFF for haemorrhoids: Systematic Review and Meta-Analysis	Complement Ther Med	2018
35752073	Efficacy and safety of MPFF for postoperative hemorrhoid complications: Meta-Analysis	Phytomedicine	2022
29934701	Flavonoid mixture (diosmin, troxerutin, rutin, hesperidin, quercetin) in I-III degree hemorrhoidal disease: RCT	Int J Colorectal Dis	2018
42392851	Efficacy of escin combined with MPFF in acute internal hemorrhoids: RCT	Ann Coloproctol	2026
32409760	Comparison of Centella with Flavonoids for Hemorrhoidal Disease: RCT	Sci Rep	2020
42442141	Mesoglycan in the acute phase of hemorrhoidal disease (CHORMES): double-blind RCT	Surgery	2026

Behandeling: aanvullende bronnen

PMID	Titel	Tijdschrift	Jaar
42205186	Oral phlebotonics for conservative management of hemorrhoidal disease (VIVALDI)	Front Surg	2026
30972964	Escin suppresses HMGB1-induced aquaporin-1 and increased permeability in endothelial cells	FEBS Open Bio	2019
27825178	Ruscus Genus: A Rich Source of Bioactive Steroidal Saponins	Planta Med	2016
40819781	Chemical composition and anti-inflammatory properties of witch hazel bark (Hamamelis virginiana)	J Ethnopharmacol	2025

Methodologische noot

Twee kernbronnen (de GWAS in Gut 2021, PMID 33888516, en de microbioom-theorie in J Clin Med 2023, PMID 36983199) zijn via PubMed geverifieerd op titel, auteurs en abstract; van deze twee is de volledige tekst niet ingezien. De theorie-indeling en de microbioom-hypothese in dit dossier rusten op de review-samenvatting en worden nadrukkelijk als hypothese gepresenteerd. Zie pathofysiologie.