Health Cockpit Research

Onderdeel van het Appendicitis-dossier van Health Cockpit, het praktijkmanagement-platform voor functioneel werkende therapeuten.

Referenties

Antibiotica versus chirurgie bij volwassenen

Salminen P, Tuominen R, Paajanen H, et al. Five-Year Follow-up of Antibiotic Therapy for Uncomplicated Acute Appendicitis in the APPAC Randomized Clinical Trial. JAMA 2018;320(12):1259-1265. PMID 30264120.
Salminen P, Salminen R, Kallio J, et al. Antibiotic Therapy for Uncomplicated Acute Appendicitis: Ten-Year Follow-Up of the APPAC Randomized Clinical Trial. JAMA 2026 Mar. PMID 41563747.
Scheijmans JCG, Haijanen J, Flum DR, et al. Antibiotic treatment versus appendicectomy for acute appendicitis in adults: an individual patient data meta-analysis. The Lancet Gastroenterology & Hepatology 2025;10(3). PMID 39827891.

St Peter SD, Noel-MacDonnell JR, Hall NJ, et al. Appendicectomy versus antibiotics for acute uncomplicated appendicitis in children: an open-label, international, multicentre, randomised, non-inferiority trial. The Lancet 2025 Jan. PMID 39826968.

Wang J, Yin J, Wang C, Zhu Y. The safety and efficacy of appendectomy, endoscopic retrograde appendicitis therapy, and antibiotic treatment for acute uncomplicated appendicitis: a systematic review and network meta-analysis of randomized controlled trials. BMC Surgery 2025 Oct. PMID 41044518.
Li Z, Chen Y, Zhang X, Zhu J, Liang Z. Feasibility and effectiveness of endoscopic retrograde appendicitis therapy for uncomplicated acute appendicitis: a systematic review and meta-analysis. Surgical Endoscopy 2025 Jul. PMID 40369281.

Role of Preoperative Antibiotic Treatment While Awaiting Appendectomy: The PERFECT-Antibiotics Randomized Clinical Trial. JAMA Surgery 2025. PMID 40366704.
Evaluating the necessity of post-operative antibiotics in uncomplicated appendicitis: a systematic review and meta-analysis. BMC Surgery 2025. PMID 41176598.

Blohs M, Mahnert A, Brunnader K, et al. Acute appendicitis manifests as two microbiome state types with oral pathogens influencing severity. Gut Microbes 2023;15(1). PMID 36691230.
Karikis I, Arda Y, Sanyal R, et al. Acute Appendicitis and the Microbiome: A Review of Microbial Signatures. Surgical Infections 2025 Dec. PMID 41468056.
Causal effects of gut microbiota on appendicitis: a two-sample Mendelian randomization study. Frontiers in Cellular and Infection Microbiology 2023. PMID 38162578.

Vitetta L, Chen J, Clarke S. The vermiform appendix: an immunological organ sustaining a microbiome inoculum. Clinical Science 2019;133(1):1-8. PMID 30606811.
Weinstein PD, Mage RG, Anderson AO. The appendix functions as a mammalian bursal equivalent in the developing rabbit. Advances in Experimental Medicine and Biology 1994. PMID 7709830.
Sahami S, Kooij IA, Meijer SL, et al. The Link between the Appendix and Ulcerative Colitis: Clinical Relevance and Potential Immunological Mechanisms. American Journal of Gastroenterology 2016;111(2). PMID 26416189.

Wu X, He C, Liu C, et al. Mechanisms of JinHong Formula on treating sepsis explored by randomized controlled trial combined with network pharmacology. Journal of Ethnopharmacology 2023. PMID 36539071.
Zhang W, Sun C, Zhou S, et al. Recent advances in chemistry and bioactivity of Sargentodoxa cuneata. Journal of Ethnopharmacology 2021. PMID 33460761.
Wang SH, Ou SC, Lin TY, Chang TT. Alternative therapy for acute appendicitis with appendicolith using traditional Chinese medicine: A case report. Explore (NY) 2024. PMID 38290897.
Ogawa-Ochiai K, Yoshimura K, Shirai A, et al. Study protocol for daiobotanpito combined with antibiotic therapy for treatment of acute diverticulitis: a study protocol for a randomized controlled trial. Trials 2020;21(1). PMID 32546262.
Huang H, Su M, Liu F, Long W. Combination of acupoint herbal plaster and ear acupuncture for effective pain relief in patients after laparoscopic appendectomy. Pakistan Journal of Pharmaceutical Sciences 2025. PMID 40824014.

Bickler SW, DeMaio A. Western diseases: current concepts and implications for pediatric surgery research and practice. Pediatric Surgery International 2008;24(3). PMID 18087704.
Walker AR, Segal I. Appendicitis: an African perspective. Journal of the Royal Society of Medicine 1995;88(11). PMID 8544144.

Rutgeerts P, D’Haens G, Hiele M, Geboes K, Vantrappen G. Appendectomy protects against ulcerative colitis. Gastroenterology 1994;106(5):1251-3. PMID 8174886.
Radford-Smith GL, Edwards JE, Purdie DM, et al. Protective role of appendicectomy on onset and severity of ulcerative colitis and Crohn’s disease. Gut 2002;51(6). PMID 12427781.
Deng P, Wu J. Meta-analysis of the association between appendiceal orifice inflammation and appendectomy and ulcerative colitis. Revista Española de Enfermedades Digestivas 2016;108(7). PMID 27338627.
Agrawal M, Allin KH, Mehandru S, et al. The appendix and ulcerative colitis - an unsolved connection. Nature Reviews Gastroenterology & Hepatology 2023;20(9). PMID 37081213.
Liu D, Dan W, Yan B, Peng L, Pan F. Evidence for genetic correlation between appendix and inflammatory bowel disease: A bidirectional Mendelian randomization study. PLoS One 2026. PMID 41671252.
Cheluvappa R. A novel model of appendicitis and appendectomy to investigate inflammatory bowel disease pathogenesis and remediation. Biological Procedures Online 2014;16(1):10. PMID 24999306.